曾伟伟(硕士生导师)
姓名: 曾伟伟
性别:男
职称:JN江南官方 教授
个人荣誉:获得佛山科学技术学院第二届“十佳研究生师徒”称号,中国水产科学研究院珠江水产研究所工作期间,连续9年考核优秀,其中5年被评为先进个人,4年被评为表扬个人。
教育与工作简历:2006年毕业于西北农林科技大学,兽医学本科;
2009年毕业于中国农业科学院哈尔滨兽医研究所,预防兽医学硕士;
2016年毕业于华南农业大学,临床兽医学博士;
2009年至2019年,中国水产科学研究院珠江水产研究所,从事水产健康养殖和病害防控研究工作,助研、副研。
2020年至今,JN江南官方,从事水产病害防控、健康养殖及抗病遗传育种研究工作,教授;
主要研究内容和研究成果
主要从事水产病害防控和抗病遗传育种研究;具体涉及病原学研究、水产疫苗及诊断试剂盒等防控产品开发和鱼类抗病遗传育种研究;主持国家自然科学基金、省自然科学基金重点项目等科研项目40多项;发表学术论文146篇,其中SCI论文72篇;申请国家发明专利56项,授权31项,转化5项;参编专著7本,其中英文专著1本;制定国家、行业及地方标准6项;获得省科技进步二等奖等科技奖9项;开发出诊断试剂盒、疫苗、中药制剂等产品20多种。
教学与人才培养:
承担《水生动物疾病学》、《池塘养鱼学》、《养殖水环境化学》、《水产养殖技术》、《渔业信息化》等本科和研究生课程;共培养硕士研究生26名,联合培养博士研究生1名。
社会兼职:
全国水产标准化技术委员会水产养殖病害防治分技术委员会委员、广东省应急管理专家委员会委员、广东省农业产业体系岗位专家、广东省科技特派员
主持项目:
1. 国家自然科学基金面上项目,GCRVⅡ型强、弱毒株编码蛋白调控RLR信号通路中IFN应答差异的分子机制。32273169;2023.01-2026.12,主持,53万;
2. 国家自然科学基金青年基金:不同电泳带型草鱼呼肠孤病毒全基因组序列分析及基因分型研究,2013.01-2015.12,主持,20万;
3. 国家自然科学基金地区基金,罗非鱼湖病毒感染后Toll样受体介导的宿主抗病毒免疫应答机制研究,2022.01-2024.12,合作单位负责人,17.5万。
4. 国家标准制定项目,草鱼呼肠孤病毒三重RT-PCR检测方法,2015.01-2015.12,结题,主持,7.5万;
5. 国家重点研发计划子课题,水产养殖重要疾病现场快速诊断技术及产品开发,2019.10-2021.10,子课题负责人,63万;
6. 广东省自然科学基金重点项目:广东省草鱼呼肠孤病毒分子流行病学及强、弱毒株基因组分子差异研究,2017.10-2020.12,主持,50万;
7. 广东省基础与应用基础研究基金省市联合基金重点项目:基于加州鲈单倍体胚胎干细胞的抗病毒机制研究及在抗病育种中的应用(2023B1515120074 );2023.11-2026.10,主持,100万;
8. 广东省自然科学基金面上项目,STING介导RIG-I样受体信号通路诱导I型干扰素抗罗湖病毒作用的分子机制, 2022/01-2024/12,主持,10万;
9. 行业标准制定项目,草鱼出血病流行病学调查规范制度,2013.01-2013.12,结题,主持,7万;
10. 广东省科技计划项目:草鱼呼肠孤病毒强毒株与疫苗株快速鉴别诊断及其抗体ELISA检测技术研究,2015.05-2017.12,结题,主持,15万;
11. 广东省渔港建设和渔业发展专项:草鱼呼肠孤病毒三重RT-PCR检测试剂盒推广, 2016.06 -2018.12,主持,50万;
12. 广东省现代农业产业共性关键技术研发创新团队,动物疫病监测与综合防控共性关键技术创新团队(水产部分),监测与信息化,2019.01-2023.12,岗位专家,43万;
13. 广东省促进经济高质量发展专项资金海洋经济发展项目 水产品主要病原菌快速检测技术开发及应用,2019.4- 2021.4 ,主持,100万;
14. 行业标准制定项目,草鱼出血病监测技术规范,2019.01-2020.12,在研,主持,10万;
15. 广西省重点研发计划,淡水鱼出血性疾病新型疫苗的研制及产业化应用关键技术研究,2021.12-2024.12,,子项目负责人,80.5万;
16. 江西省科技支撑计划科研专项:江西省重大水生动物疫病监测及流行规律与防控技术的研究,2015.07-2017.10,子项目负责人,20万;
17. 广东省海洋与渔业厅,广东省促进经济发展专项,草鱼和罗非鱼免疫防控技术的试验与推广应用,2018.09-2020.12,结题,子项目负责人,10万;
18. 广东省企业科技特派员项目,淡水鱼细菌性败血症疫苗产业化应用关键技术研究,2020.04-2022.04,主持,10万。
19. 广州市荔湾区科技计划项目,草鱼呼肠孤病毒三重PCR检测试剂盒的推广与应用,2015.07-2017.07,主持,25万。
20. 佛山市市院合作项目,一种水产用抗应激复方制剂在淡水鱼养殖中的示范与推广,2022.01-2022.12,主持,25万。
21. 各种横向项目20多项;
主要发表的论文:
1. Weiwei Zeng, Yingying Wangb,Huzi Hub, Qing Wangb,Sven M. Bergmannc, Bo Lib,Yahui Wangb, Yuefeng Lvb, Hua Lia,Jiyuan yinb, Yingying Lib, Hui Yua. Cell culture-derived Tilapia Lake Virus inactivated vaccine containing Montanide adjuvant provides high protection against viral challenge for tilapia. Vaccines 2021, 9(2), 86.
2.Weiwei Zeng, Yingying Wangb, Xiaoyu Chend, Sven M. Bergmannc,Bo Lib,Yahui Wangb, Yuefeng Lvb, Hua Lia, Hui Yua, Qing Wangb. Potency and efficacy of VP20-based vaccine against tilapia lake virus using different prime-boost vaccination regimens in tilapia. Aquaculture 539 (2021) 736654.
3.Weiwei Zeng, Sven M Bergmannc , Hanxu Dong, Ying Yang, Minglin Wu 3, Hong Liu , Yanfeng Chen, Hua Li.Identification, Virulence, and Molecular Characterization of a Recombinant Isolate of Grass Carp Reovirus Genotype I.Viruses. 2021, 30;13(5):807. doi: 10.3390/v13050807.
4.Weiwei Zeng , *, Hanxu Dong a , Xiaoyu Chen d , Sven M. Bergmann c , Ying Yang a , Xinxian Wei b ,Guixiang Tongb , Hua Li a , Hui Yu a ,Yanfeng Chen. Establishment and characterization of a permanent heart cell line fromlargemouth bass Micropterus salmoides and its application to fish virology and immunology.Aquaculture, 547 (2022), 737427.
5.Weiwei Zeng,QingWang,Yingying Wang,Le sheng Zhang,Shuqin Wu.A one-step molecular biology method for simple and rapid detection of grass crap ( Ctenopharyngodon idella) reovirus (GCRV) HZ08 strain , Journal of Fish Biology 2013, 82, 1545–1555.
6.Weiwei Zeng1,Qing Wang1,Yingying Wang, HongruLiang , Cun Liu, Xiang Fang, Shuqin Wu*.Genomic characterization and taxonomic position of a rhabdovirus from the hybrid snakehead,Archives of Virology,2014,159(9): 2469-2473.
7. Weiwei Zeng,Yingying Wang, Hongru Liang, Cun Liu , Xinjian Song, Shuqin Wu, Qing Wang. A one-step duplex rRT-PCR assay for the simultaneous detection of grass carp reovirus genotypes I and II. J Virol Methods,2014(210):32-35.
8. Weiwei Zeng a, b, Qing Wang b, *, Yingying Wang b, Changchen Zhao b, Yingying Li b,Chunbin Shi b, Shuqin Wu b, Xinjian Song b, Qiwen Huang b, Shoujun Li a,Immunogenicity of a cell culture-derived inactivated vaccine against a common virulent isolate of grass carp reovirus.Fish & Shellfish Immunology 54 (2016) 473-480.
9. WeiweiZENG,Wei YAO,Qing WANG*, Yingying WANG, Yingying Li,Sven M Bermann,Yan REN,Cunbin SHI, Xinjian SONG, Qiwen HUANG,Shuchen ZHENG。Molecular detection of genotype Ⅱ grass carp reovirus based on nucleic acid sequence-based amplification combined with enzyme-linked immunosorbent assay (NASBA-ELISA) .Journal of Virological Methods. 2017, 243:92-97.
10.Weiwei ZENG1, Yingying WANG1, Yanmin GUO3, Sven M. BERGMANN2 , Jiyuan YIN1,Yingying LI1, Yan REN1, Cunbin SHI1 Qing WANG*1. Development of a VP38 recombinant protein based indirect ELISA for detection of antibodiesagainst grass crap reovirus genotype II. Journal of fish disease, 2018,41:1811-1819.
11.Qing Wanga,1,Hualiang Xie a,b,1,Weiwei Zenga,*,Linchuan Wangb, Chun Liua, Jiexing Wua,YingyingWanga, Yingying Lia , Sven M. Bergmannc. Developmentof indirect immunofluorescence assay for TCID50 measurementof grass carp reovirus genotype II without cytopathic effect onto cell. Microbial Pathogenesis 114 (2018) 68-74.
12.Guo Y M, Zeng W W*, Wang Q ,Wang Y Y, Li YY, Yin JY, Ren Y, Shi C B.Use of high-resolution melting curveanalysis to differentiate vaccine and wild type strains of grass carp reovirusgenotype II.Journal of Virological Methods. 2018, doi: 10.1016/j.jviromet.2018.03.006.
13.Yingying Wang,Qing Wang,Weiwei Zeng∗,Jiyuan Yin,Yingying Li,Yan Ren,Cunbin Shi,Sven M. Bergmann,Xinping Zhu. Establishment and Characterization of a Cell Line from Tilapia Brain for detection of Tilapia Lake Virus. Journal of fish disease, 2018,41:1803-1809.
14.Yin J, Wang Q, Wang Y, Li Y, Zeng W*, Wu J, Ren Y, Tang Y, Gao C,Hu H, Bergmann SM.Development of a simple and rapid reverse transcription-loopmediated isothermal amplification (RT-LAMP) assay for sensitive detection of tilapia lake virus.Journal of Fish
15.Disease,2019,42(6):817-824.
16. Huzi Hu,Weiwei Zeng*,Yingying Wang, Qing Wang, Sven M.Bergmann, Jiyuan Yin, Yingying Li, Xiaoyu Chen, Caixia Gao, Defeng Zhang, ChunLiu, Yan Ren, Cunbin Shi.Development and application of a recombinant protein-based indirect ELISA for detection of anti-tilapia lake virus IgM in sera from tilapia. Aquaculture,2019:734756.
17.YingyingWanga,b, Qing Wanga,*, Yingying Lia, Jiyuan Yina, Yan Rena, Cunbin Shia,Sven M.Bergmannc, Xinping Zhua,b, Weiwei Zengd,**.Integrated analysis of mRNA-miRNA expression in Tilapia infected withTilapia lake virus(TiLV) and identifies primarily immuneresponse genes.Fish and Shellfish Immunology, 99 (2020)208-226.
18. Yafang Tanga,b, Weiwei Zenga,∗, Yingying Wanga, Qing Wanga, Jiyuan Yina, Yingying Lia,ChengbaoWangb, Sven M. Bergmannc, Caixia Gaoa,d, Huzi Hua,d。Comparison of the blood parameters and histopathologybetween grass carp infected with a virulent and avirulent isolates of genotype II grasscarp reovirus.Microbial Pathogenesis 139(2020)103859.
19.FengCongb,1, Fanwen Zengb,c,1, Miaoli Wub,1, Jingjing Wangd, Bihong Huangb,Yingying Wanga,Qing Wanga, Shouquan Zhangc, Lei Mab, Pengju Guob,, WeiweiZenga*, Development of a real-time reverse transcription recombinase polymerase amplification assay for rapid detection of spring viremia of carp virus.Molecular and cellular Probes.50(2020)101494.
20.YingyingWang, Qing Wang, Weiwei Zeng*,Yingying Li, Jiyuan Yin, Sven M. Bergmann, Xinping Zhu*. Establishment of a brain cellline obtained from hybrids of Channa argus ×Channa maculata for the detectionof tilapia lake virus. Microbial Pathogenesis, 2020, 138: 103810.
21.Jiaming Chen, Ouqin Chang, Yingying Li, Yingying Wang, Chao Liu, Jiyuan Yin, Sven M. Bergmann, Weiwei Zeng*, Qing Wang. Establishment of a rare minnow (Gobiocypris rarus) disease model for grass carp reovirus genotype II. Aquaculture 533 (2021) 736133.
22.Yang Qu, Qing Wang, Yingying Li, Yingying Wang, Jiyuan Yin, Yan Ren, Chun Liu, Xiaofang Liu, Yahui Wang, Weiwei Zeng*. Development of a real-time recombinase polymerase amplification assay for rapid detection of Aeromonas hydrophila. Journal of Fish Diseases, 2020.DOI: 10.1111/jfd.13291.
23.Gen Li, feng cong, Weiyou Cai, Jinhui Li, Miaoli Wu, li xiao, Weiwei zeng*, Xiaoliang Hu .Development of a recombinase polymerase amplification (RPA) fluorescence assay for the detection of Enterocytozoon hepatopenaei (EHP).Aquaculture Reports 19 (2021) 100584.
24.Ye Ge, Qiucheng Yao,Yingying Wang*, Qing Wang*,Weiwei Zeng*. Deep illumine miRNA Sequencing Provides Insights into the Mechanism Underlying Grass Carp Reovirus Infection. Aquaculture Research,2020,00:1-8.DOI: 10.1111/are.14904.
25.Qiucheng Yao1 , Mengdi Zhang 1 , Shaopo Zu 3 , Hong Yang 4 , Weitian Xie 1 , Jinjun Chen 1 , Zhibao Chen 1 , Ye Ge,1 Zhihui Zhao 1 * ,Weiwei Zeng 2* ,Integrated mRNA and microRNA transcriptome sequencing characterizes sequence variants and mRNA–microRNA regulatory networks in grass carp fibroblasts infected with virulent and attenuated GCRV,Marine Biotechnology (2021) 23:342–355.
26.Yingying Wang, Zhili Li, Qing Wang, Weiwei Zeng*, Yingying Li, Jiyuan Yin,Sven M. Bergmann, Xinping Zhu. Establishment of a brain cell line obtained from hybrids of Channa argus×Channa maculata for the detection of tilapia lake virus. Microbial Pathogenesis, 2020,138:103810.
27.Cai xia Gao, Yingying Wang, Huzi Hu, Wenli Zhou, Jiyuan Yin, Yingying Li, Sven M. Bergmann, Siyu Wu, Qing Wang,Weiwei Zeng*. Assessment of a natural grass carp reovirus genotype II avirulent strain GD1108 shows great potential as an avirulent live vaccine, Microbial Pathogenesis, .
28.Yuefeng Lv, Yingying Wang, Qing Wang, Yingying Li,Jiyuan Yin, Guang Yang, Cunbin Shi, Bo Li, Yahui Wang, Sven M. Bergmann, Weiwei Zeng. Development and characterization of a new cell line from brain tissues of the rare minnow (Gobiocypris rarus).Aquaculture Research. 2021;00:1-12.
29.Zhishen Huang ac,, Yingying Wang a, Jiyuan Yin a, Yingying Li a, Sven M. Bergmannd, Caixia Gaoac,Yahui Wangac,Weiwei Zengb *,Qing Wang. An iTRAQ-based comparative proteomic analysis of grass carp spleen infected with virulent and avirulent isolates of genotype II grass carp reovirus . Aquaculture 535 (2021) 736426.
30.Yahui Wang,Qing Wang, Sven M. Bergmann,Bo Li, Yuefeng Lv, Qing Wang,Yingying Wang,Weiwei Zeng *. Rapid and sensitive detection of tilapia lake virus by real-time reverse transcription recombinase polymerase amplification.Molecular and Cellular Probes 60 (2021) 101776.
31.Qing Wang1, Weiwei Zeng1, Chun Liu, Chao Zhang, Yingying Wang, Cunbin Shi, Shuqin Wu. Complete genome sequence of a reovirus isolated from grass carp indicating different
32.genotypes of GCRV in China. Journal of virology.2012, 86(22):12466.
33.Qing Wang1, Weiwei Zeng1, KaibinB Li1 Ouqin Chang, Chun Liu, Guanghui Wu, CunbinB Shi, Shuqin Wu.Outbreaks of an iridovirus in Marbled Sleepy Goby, Oxyeleotris marmoratus, cultured in southern China.Journal of fish diseases.2011, 34:399–402.
34.YingyingWang1, Weiwei Zeng 1, Yingying Li, Hongru Liang , Chun Liua, Houjun Pan, Peiyu Lee ,Shuqin Wu, Sven M. Bergmann , QingWang . Development and characterization of a cell line from the snout of koi (Cyprinus carpio L.) for detection of koi herpesvirus. Aquaculture 435 (2015) 310–317.
35.Qing Wang1, Weiwei Zeng1, Liang Yin, Yingying Wang, Chun Liu, Yingying Li, Shucheng Zheng and Cunbin Shi.Comparative Study on Physical–Chemical and Biological Characteristics of Grass Carp Reovirus From Different Genotypes.Journal of the World Aquaculture Society.15 JUL 2016, DOI: 10.1111/jwas.12326.
36. 曾伟伟,石星明,黄婷婷等,王玫,高宏博,孙妍,李继松,王云峰。纹身法免疫增强DNA疫苗免疫效果的评价[J].畜牧兽医学报.2009,40(7)1048-1053。
37. 曾伟伟,石星明,高宏博,王玫,黄婷婷,李继松,孙妍,崔红玉,童光志,王云峰。密码子优化增强新城疫病毒DNA疫苗的表达水平和免疫效果[J].中国动物传染病学报 .2009,17 (2) :8-16。
38. 曾伟伟,王庆,石存斌,吴淑勤.分子生物学技术在水产动物疾病诊断中的应用进展.动物医学进展.2010,31(6):111-117。
39. 曾伟伟,王庆,刘永奎等.吴淑勤.一株草鱼呼肠孤病毒的分离、鉴定及免疫原性初步分析. 水产学报。2011,35(5):790-795。
40. 曾伟伟,王庆,张乐生,刘宝芹,刘永奎,石存斌,曾令兵,吴淑勤。草鱼呼肠孤病毒HZ08株VP4蛋白的原核表达、纯化及多克隆抗体的制备。生物制品学杂志,2011,24(12):1-4。
41. 曾伟伟,王庆,张超,张乐生,刘宝芹,刘永奎,石存斌,吴淑勤。草鱼呼肠孤病毒HZ08株S4全基因序列分析.生物学杂志。2012 ,29(2)12-17。
42. 曾伟伟, 王庆, 王英英, 张乐生, 刘宝芹, 石存斌, 吴淑勤。草鱼呼肠孤病毒三重RT-PCR检测方法的建立及其初步应用。中国水产科学。2013,20(2):419-426。
43. 曾伟伟,王 庆,王英英,石存斌,吴淑勤。草鱼呼肠孤病毒HZ08株VP5蛋白单克隆抗体的制备与鉴定。水产学报。2013,37(3):450-456.
44. 曾伟伟,王 庆,王英英,谭爱萍,刘春,石存斌,吴淑勤。杂交鱧(乌鳢x斑鱧)一株鳢科源弹状病毒病原的分离与鉴定。水产学报。2013,37:(7):1416-1424。
45. 曾伟伟,王庆,王英英,李莹莹, 郝贵杰,石存斌,沈锦玉,草鱼呼肠孤病毒HZ08株抗体IPMA检测方法的建立及应用,水产学报,2017,41(1):142~149。
46. 曾伟伟,巩华,王英英,李莹莹,石存斌,任燕,赵长臣,王庆。草鱼呼肠孤病毒三重RT-PCR试剂盒的操作方法及应用。珠江水产科学。2017(1):41-44.
47. 曾伟伟,王英英,尹纪元,汤亚方,王庆*,李莹莹,高彩霞,任燕,刘春,石存斌。Ⅱ型草鱼呼肠孤病毒三种定量检测方法的比较与评价。淡水渔业,2019,49(6):3-11.
48. 任鹏丽;陈庭金;黄艳;曾伟伟*;余新炳*;草鱼呼肠孤病毒HZ08株外衣壳蛋白VP4的节段克隆表达和免疫学分析,热带医学杂志,2016,16(2):140-144.
49.汤亚方,曾伟伟*,王庆,王英英,石存斌,冯茹,高辉,王承宝。反向遗传操作技术在呼肠孤病毒中的研究与应用。病毒学报。2017,33(6):950-958。
50.黄琦雯,王庆,王英英,李莹莹,石存斌,任燕,高彩霞,吴杰兴,郑树城,曾伟伟*。基因Ⅱ型草鱼呼肠孤病毒TaqMan Real-Time PCR检测方法的建立与应用。中国预防兽医学报。2017(10):715-722.
51.高彩霞,曾伟伟*,汤亚方,王英英,王庆,周文礼,吴杰兴,刘世旭,尹纪元,李莹莹。两株Ⅱ型草鱼呼肠孤病毒的分离、鉴定及生物学特性比较。水产学报,2020,44(6): 1013−1024。
52.胡虎子,曾伟伟*,王英英,王庆,尹纪元,李莹莹,周文礼,高彩霞,渠洋,王雅慧,李波。罗非鱼湖病毒病研究进展。病毒学报,2020,36(01):145-154。
53. 汤亚方,曾伟伟*,王庆,王英英,石存斌,冯茹,高辉,王承宝。草鱼呼肠孤病毒Ⅱ型VP6蛋白多克隆抗体及其特异性分析。淡水渔业,2018,48(1):3-11.
54.刘伟强,靳育琦,董寒旭,麦倩仪,孙冬丽,吴雅丽,赖明建,曾伟伟*。益生菌在水产养殖病害防控中的应用。动物医学进展,2023,44(8):112-116.
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