杨正涛（硕士生导师）

杨正涛 教授，1973年2月生于甘肃省酒泉市，中国共产党党员，佛山科学技术学院教授，硕士生导师，吉林大学动物医学学院博士生导师。中国畜牧兽医学会兽医内科与动物诊疗分会常务理事。主要承担动物医学专业本科兽医临床诊断学、兽医内科学，动物科学专业本科兽医概论、兽医各论，研究生临床病理学，兽医临床症状鉴别诊断学等教学任务和兽医临床实践工作。

联系方式：18689272113  yangzt@fosu.edu.cn

 

一、教育学历

1992.09－1997.07 解放军兽医大学兽医专业，学士学位。

2000.09－2003.07 解放军军需大学临床兽医学专业，硕士学位。

2005.09－2010.07吉林大学临床兽医学专业，博士学位。

二、工作经历

1997.08-1998.08 军事医学科学院实验动物中心，助理兽医师。

1998.09-1999.08 解放军农牧（军需）大学兽医内科学教研室助教。

1999.08-2004.09吉林大学临床兽医学系 讲师。

2008.09-2017.09吉林大学临床兽医学系 副教授，硕士生导师。

2015.07-吉林大学临床兽医学系 博士生导师。

2016.03-2017.03 德国吉森大学 访问学者。

2017.04-吉林大学临床兽医学系 教授。

2019.04-佛山科学技术学院 兽医系教授。

三、研究兴趣

畜禽非特定病原体感染性疾病的免疫学防治；天然免疫TLR信号转导通路在寄生虫病，过敏性疾病，自身免疫性疾病发病过程中的作用机制；天然结构化合物（中药单体）、微量元素、维生素及激素等对先天免疫信号转导的影响机制；基于TLR信号转导通路的免疫调节策略用于畜禽疾病防治的研究。

四、承担课题

1、广东省现代草牧业（羊）产业技术体系繁殖技术与繁殖体系，2019-2024，经费40.0万元。

2、奶牛中性粒细胞胞外诱捕网对乳腺上皮损伤的作用研究，国家自然科学基金面上项目（项目编号：31772721）2018-2021年，经费62.0万元。

3、非酯化脂肪酸对隐性乳腺炎奶牛中性粒细胞跨内皮迁移的影响机制，国家自然科学基金面上项目（编号：31572583）2016-2017，经费29.7万元

4、新型牛羊阴离子盐添加剂和防控犊牛腹泻电解质产品开发，科技部“十三五”国家重点研发计划子课题（编号：2016YFD0501203）2016-2020，经费67.5万元。

5、宿主抗新孢子虫感染先天免疫NLRs信号转导通路，科技部国家重点基础研究计划（973）子课题（编号：2015CB150306-2）2015-2019，80.0万元。

6、Caco-2细胞TLR/自噬途径在抗隐孢子虫感染中的作用。博士后科学基金面上项目（编号：2013M540255）2013-2014，经费8.0万元。

五、发表成果

[1] J. Wang, Z. Wu, X. Zhu, P. Li, Y. Fu, X. Wang, Y. Sun, E. Zhou, Z. Yang, Lysine-specific demethylase 1 (LSD1) serves as an potential epigenetic determinant to regulate inflammatory responses in mastitis, International immunopharmacology 91 (2021).

[2] E. Zhou, Z. Wu, X. Zhu, P. Li, J. Wang, Z. Yang, Histamine triggers the formation of neutrophil extracellular traps via NADPH oxidase, ERK and p38 pathways, Veterinary Immunology and Immunopathology 235 (2021).

[3] W. Liu, D. Wu, S. Li, J. Xu, P. Li, A. Jiang, Y. Zhang, Z. Liu, L. Jiang, X. Gao, Z. Yang, Z. Wei, Glycolysis and Reactive Oxygen Species Production Participate in T-2 Toxin-Stimulated Chicken Heterophil Extracellular Traps, Journal of agricultural and food chemistry 69 (2021) 12862-12869.

[4] Y.-C. Wang, Z. Wei, X. Lv, S. Han, Z. Wang, C. Fan, X. Zhang, J. Shao, Y.-H. Zhao, L. Sui, C. Chen, M. Liao, B. Wang, N. Jin, C. Li, J. Ma, Z.-J. Hou, Z. Yang, Z. Han, Y. Zhang, J. Niu, W. Wang, Y. Wang, Q. Liu, A new nairo-like virus associated with human febrile illness in China, Emerging Microbes & Infections 10 (2021) 1200-1208.

[5] Y. Zhang, Z. Han, A. Jiang, D. Wu, S. Li, Z. Liu, Z. Wei, Z. Yang, C. Guo, Protective Effects of Pterostilbene on Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting NF-kappa B and Activating Nrf2/HO-1 Signaling Pathways, Frontiers in Pharmacology 11 (2021).

[6] A. Jiang, Y. Zhang, D. Wu, S. Li, Z. Liu, Z. Yang, Z. Wei, Sodium molybdate induces heterophil extracellular traps formation in chicken, Ecotoxicology and Environmental Safety 210 (2021).

[7] X. Liu, Y. Fu, J. Wang, D. Wu, S. Li, C. Wang, Z. Yang, E. Zhou, beta-Conglycinin induces the formation of neutrophil extracellular traps dependent on NADPH oxidase-derived ROS, PAD4, ERK1/2 and p38 signaling pathways in mice, Food & Function 12 (2021) 154-161.

[8] D. Wu, S. Li, P. Li, A. Jiang, Z. Liu, Y. Zhang, J. Wang, Z. Yang, Z. Wei, Diacetoxyscirpenol-induced heterophil extracellular traps contribute to the immune toxicity of liver injury in chickens, Food and Chemical Toxicology 148 (2021).

[9] D. Wu, S. Li, X. Liu, J. Xu, A. Jiang, Y. Zhang, Z. Liu, J. Wang, E. Zhou, Z. Wei, Z. Yang, C. Guo, Alpinetin prevents inflammatory responses in OVA-induced allergic asthma through modulating PI3K/AKT/NF-kappa B and HO-1 signaling pathways in mice, International immunopharmacology 89 (2020).

[10] C. Wang, J. Wang, X. Liu, Z. Han, A. jiang, Z. Wei, Z. Yang, Cl-amidine attenuates lipopolysaccharide-induced mouse mastitis by inhibiting NF-kappa B, MAPK, NLRP3 signaling pathway and neutrophils extracellular traps release, Microbial Pathogenesis 149 (2020).

[11] J. Wang, Z. Liu, Z. Han, Z. Wei, Y. Zhang, K. Wang, Z. Yang, Fumonisin B-1 triggers the formation of bovine neutrophil extracellular traps, Toxicology letters 332 (2020) 140-145.

[12] A. Jiang, Y. Zhang, X. Zhang, D. Wu, Z. Liu, S. Li, X. Liu, Z. Han, C. Wang, J. Wang, Z. Wei, C. Guo, Z. Yang, Morin alleviates LPS-induced mastitis by inhibiting the PI3K/AKT, MAPK, NF-kappa B and NLRP3 signaling pathway and protecting the integrity of blood-milk barrier, International immunopharmacology 78 (2020).

[13] L. Jiang, J. Wang, Z. Liu, A. Jiang, S. Li, D. Wu, Y. Zhang, X. Zhu, E. Zhou, Z. Wei, Z. Yang, Sodium Butyrate Alleviates Lipopolysaccharide-Induced Inflammatory Responses by Down-Regulation of NF-kappa B, NLRP3 Signaling Pathway, and Activating Histone Acetylation in Bovine Macrophages, Frontiers in Veterinary Science 7 (2020).

[14] J.-J. Wang, Z.-K. Wei, Z. Han, Z.-Y. Liu, Y. Zhang, X.-Y. Zhu, X.-W. Li, K. Wang, Z.-T. Yang, Sodium fluoride exposure triggered the formation of neutrophil extracellular traps, Environmental Pollution 257 (2020).

[15] Z. Wei, T. Yu, J. Wang, C. Wang, X. Liu, Z. Han, X. Zhang, Y. Zhang, H. Ouyang, Z. Yang, Swine sperm induces neutrophil extracellular traps that entangle sperm and embryos, Reproduction 160 (2020) 217-225.

[16] Z. Wei, Z. Wang, X. Liu, C. Wang, Z. Han, D. Wu, Y. Zhang, X. Zhang, Z. Yang, Q. Liu, Toxoplasma gondiiTriggers Neutrophil Extracellular Traps Release in Dogs, Frontiers in cellular and infection microbiology 10 (2020).

[17] J.-J. Wang, Z.-K. Wei, Z. Han, Z.-Y. Liu, X.-Y. Zhu, X.-W. Li, K. Wang, Z.-T. Yang, Zearalenone Induces Estrogen-Receptor-Independent Neutrophil Extracellular Trap Release in Vitro, Journal of agricultural and food chemistry 67 (2019) 4588-4594.

[18] Z. Han, Y. Zhang, C. Wang, X. Liu, A. Jiang, Z. Liu, J. Wang, Z. Yang, Z. Wei, Ochratoxin A-Triggered Chicken Heterophil Extracellular Traps Release through Reactive Oxygen Species Production Dependent on Activation of NADPH Oxidase, ERK, and p38 MAPK Signaling Pathways, Journal of agricultural and food chemistry 67 (2019) 11230-11235.

[19] C. Wang, Z. Wei, Z. Han, J. Wang, X. Zhang, Y. Wang, Q. Liu, Z. Yang, Neutrophil extracellular traps promote cadmium chloride-induced lung injury in mice, Environmental Pollution 254 (2019).

[20] C. Wang, X. Liu, Z. Han, X. Zhang, J. Wang, K. Wang, Z. Yang, Z. Wei, Nanosilver induces the formation of neutrophil extracellular traps in mouse neutrophil granulocytes, Ecotoxicology and Environmental Safety 183 (2019).

[21] X. Liu, Y. Wang, D. Wu, S. Li, C. Wang, Z. Han, J. Wang, K. Wang, Z. Yang, Z. Wei, Magnolol Prevents Acute Alcoholic Liver Damage by Activating PI3K/Nrf2/PPAR gamma and Inhibiting NLRP3 Signaling Pathway, Frontiers in Pharmacology 10 (2019).

[22] Z. Wei, Y. Zhao, N. Zhang, Z. Han, X. Liu, A. Jiang, Y. Zhang, C. Wang, P. Gong, J. Li, X. Zhang, Z. Yang, Eimeria tenella induces the release of chicken heterophil extracellular traps, Veterinary Parasitology 275 (2019).

[23] Z. Wei, J. Wang, Y. Wang, C. Wang, X. Liu, Z. Han, Y. Fu, Z. Yang, Effects of Neutrophil Extracellular Traps on Bovine Mammary Epithelial Cells in vitro, Frontiers in immunology 10 (2019).

[24] Z. Wei, X. Zhang, J. Wang, Y. Wang, Z. Yang, Y. Fu, The formation of canine neutrophil extracellular traps induced by sodium arsenic in polymorphonuclear neutrophils, Chemosphere 196 (2018) 297-302.

[25] Z. Wei, X. Zhang, Y. Wang, J. Wang, Y. Fu, Z. Yang, Nickel (II) nitrate hexahydrate triggered canine neutrophil extracellular traps release in vitro, Chemosphere 208 (2018) 117-121.

[26] J.-J. Wang, Z.-K. Wei, X. Zhang, Y.-N. Wang, Y.-h. Fu, Z.-T. Yang, Butyrate protects against disruption of the blood-milk barrier and moderates inflammatory responses in a model of mastitis induced by lipopolysaccharide, British journal of pharmacology 174 (2017) 3811-3822.

[27] Y. Wang, X. Zhang, L. Zhao, M. Shi, Z. Wei, Z. Yang, C. Guo, Y. Fu, Costunolide protects lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by inhibiting NF-kappa B signaling pathway, Journal of Surgical Research 220 (2017) 40-45.

[28] Y. Wang, X. Zhang, Z. Wei, J. Wang, Y. Zhang, M. Shi, Z. Yang, Y. Fu, Platycodin D suppressed LPS-induced inflammatory response by activating LXR alpha in LPS-stimulated primary bovine mammary epithelial cells, European journal of pharmacology 814 (2017) 138-143.

[29] J. Wang, Z. Wei, X. Zhang, Y. Wang, Z. Yang, Y. Fu, Propionate Protects against Lipopolysaccharide-Induced Mastitis in Mice by Restoring Blood-Milk Barrier Disruption and Suppressing Inflammatory Response, Frontiers in immunology 8 (2017).

[30] X. Zhang, Y. Wang, C. Xiao, Z. Wei, J. Wang, Z. Yang, Y. Fu, Resveratrol inhibits LPS-induced mice mastitis through attenuating the MAPK and NF-kappa B signaling pathway, Microbial Pathogenesis 107 (2017) 462-467.

[31] Z. Wei, C. Xiao, C. Guo, X. Zhang, Y. Wang, J. Wang, Z. Yang, Y. Fu, Sodium acetate inhibits Staphylococcus aureus internalization into bovine mammary epithelial cells by inhibiting NF-kappa B activation, Microbial Pathogenesis 107 (2017) 116-121.

[32] X. He, Z. Wei, J. Wang, J. Kou, W. Liu, Y. Fu, Z. Yang, Alpinetin attenuates inflammatory responses by suppressing TLR4 and NLRP3 signaling pathways in DSS- induced acute colitis, Scientific reports 6 (2016).

[33] J. Wang, C. Guo, Z. Wei, X. He, J. Kou, E. Zhou, Z. Yang, Y. Fu, Morin suppresses inflammatory cytokine expression by downregulation of nuclear factor-kappa B and mitogen-activated protein kinase (MAPK) signaling pathways in lipopolysaccharide-stimulated primary bovine mammary epithelial cells, Journal of Dairy Science 99 (2016) 3016-3022.

[34] X. He, C. Li, Z. Wei, J. Wang, J. Kou, W. Liu, M. Shi, Z. Yang, Y. Fu, Protective role of apigenin in cisplatin-induced renal injury, European journal of pharmacology 789 (2016) 215-221.

[35] Z. Wei, J. Wang, M. Shi, W. Liu, Z. Yang, Y. Fu, Saikosaponin a inhibits LPS-induced inflammatory response by inducing liver X receptor alpha activation in primary mouse macrophages, Oncotarget 7 (2016) 48995-49007.

[36] Z. Yang, Y. Fu, P. Gong, J. Zheng, L. Liu, Y. Yu, J. Li, H. Li, J. Yang, X. Zhang, Bovine TLR2 and TLR4 mediate Cryptosporidium parvum recognition in bovine intestinal epithelial cells, Microbial Pathogenesis 85 (2015) 29-34.

[37] Z. Wei, X. He, J. Kou, J. Wang, L. Chen, M. Yao, E. Zhou, Y. Fu, C. Guo, Z. Yang, Renoprotective mechanisms of morin in cisplatin-induced kidney injury, International immunopharmacology 28 (2015) 500-506.

[38] E. Zhou, Y. Fu, Z. Wei, Y. Cao, N. Zhang, Z. Yang, Cepharanthine Attenuates Lipopolysaccharide-Induced Mice Mastitis by Suppressing the NF-kappa B Signaling Pathway, Inflammation 37 (2014) 331-337.

[39] R. Gao, Y. Fu, Z. Wei, E. Zhou, Y. Li, M. Yao, X. Song, Z. Yang, N. Zhang, Chlorogenic acid attenuates lipopolysaccharide-induced mice mastitis by suppressing TLR4-mediated NF-kappa B signaling pathway, European journal of pharmacology 729 (2014) 54-58.

[40] Y. Fu, R. Gao, Y. Cao, M. Guo, Z. Wei, E. Zhou, Y. Li, M. Yao, Z. Yang, N. Zhang, Curcumin attenuates inflammatory responses by suppressing TLR4-mediated NF-kappa B signaling pathway in lipopolysaccharide-induced mastitis in mice, International immunopharmacology 20 (2014) 54-58.

[41] Y. Fu, E. Zhou, Z. Wei, W. Wang, T. Wang, Z. Yang, N. Zhang, Cyanidin-3-O-beta-glucoside ameliorates lipopolysaccharide-induced acute lung injury by reducing TLR4 recruitment into lipid rafts, Biochemical Pharmacology 90 (2014) 126-134.

[42] Y. Fu, Z. Wei, E. Zhou, N. Zhang, Z. Yang, Cyanidin-3-O-beta-glucoside inhibits lipopolysaccharide-induced inflammatory response in mouse mastitis model, Journal of Lipid Research 55 (2014) 1111-1119.

[43] Z. Wei, Y. Fu, E. Zhou, Y. Tian, M. Yao, Y. Li, Z. Yang, Y. Cao, Effects of niacin on Staphylococcus aureus internalization into bovine mammary epithelial cells by modulating NF-kappa B activation, Microbial Pathogenesis 71-72 (2014) 62-67.

[44] Y. Fu, E. Zhou, Z. Wei, X. Song, Z. Liu, T. Wang, W. Wang, N. Zhang, G. Liu, Z. Yang, Glycyrrhizin inhibits lipopolysaccharide-induced inflammatory response by reducing TLR4 recruitment into lipid rafts in RAW264.7 cells, Biochimica Et Biophysica Acta-General Subjects 1840 (2014) 1755-1764.

[45] Y. Fu, E. Zhou, Z. Wei, D. Liang, W. Wang, T. Wang, M. Guo, N. Zhang, Z. Yang, Glycyrrhizin inhibits the inflammatory response in mouse mammary epithelial cells and a mouse mastitis model, Febs Journal 281 (2014) 2543-2557.

[46] E. Zhou, Y. Fu, Z. Wei, Z. Yang, Inhibition of allergic airway inflammation through the blockage of NF-kappa B activation by ellagic acid in an ovalbumin-induced mouse asthma model, Food & Function 5 (2014) 2106-2112.

[47] E. Zhou, Y. Li, M. Yao, Z. Wei, Y. Fu, Z. Yang, Niacin attenuates the production of pro-inflammatory cytokines in LPS-induced mouse alveolar macrophages by HCA2 dependent mechanisms, International immunopharmacology 23 (2014) 121-126.

[48] E. Zhou, Y. Li, Z. Wei, Y. Fu, H. Lei, N. Zhang, Z. Yang, G. Xie, Schisantherin A protects lipopolysaccharide-induced acute respiratory distress syndrome in mice through inhibiting NF-kappa B and MAPKs signaling pathways, International immunopharmacology 22 (2014) 133-140.

[49] E. Zhou, Y. Fu, Z. Wei, Y. Yu, X. Zhang, Z. Yang, Thymol attenuates allergic airway inflammation in ovalbumin (OVA)-induced mouse asthma, Fitoterapia 96 (2014) 131-137.

[50] D. Liang, F. Li, Y. Fu, Y. Cao, X. Song, T. Wang, W. Wang, M. Guo, E. Zhou, D. Li, Z. Yang, N. Zhang, Thymol Inhibits LPS-Stimulated Inflammatory Response via Down-Regulation of NF-kappa B and MAPK Signaling Pathways in Mouse Mammary Epithelial Cells, Inflammation 37 (2014) 214-222.

[51] Z. Wei, E. Zhou, C. Guo, Y. Fu, Y. Yu, Y. Li, M. Yao, N. Zhang, Z. Yang, Thymol inhibits Staphylococcus aureus internalization into bovine mammary epithelial. cells by inhibiting NF-kappa B activation, Microbial Pathogenesis 71-72 (2014) 15-19.

[52] Y. Fu, E. Zhou, Z. Liu, F. Li, D. Liang, B. Liu, X. Song, F. Zhao, X. Fen, D. Li, Y. Cao, X. Zhang, N. Zhang, Z. Yang, Staphylococcus aureus and Escherichia coli elicit different innate immune responses from bovine mammary epithelial cells, Veterinary Immunology and Immunopathology 155 (2013) 245-252.

[53] D. Liang, Y. Sun, Y. Shen, F. Li, X. Song, E. Zhou, F. Zhao, Z. Liu, Y. Fu, M. Guo, N. Zhang, Z. Yang, Y. Cao, Shikonin exerts anti-inflammatory effects in a murine model of lipopolysaccharide-induced acute lung injury by inhibiting the nuclear factor-kappaB signaling pathway, International immunopharmacology 16 (2013) 475-480.

[54] D. Li, Y. Fu, W. Zhang, G. Su, B. Liu, M. Guo, F. Li, D. Liang, Z. Liu, X. Zhang, Y. Cao, N. Zhang, Z. Yang, Salidroside attenuates inflammatory responses by suppressing nuclear factor-kappa B and mitogen activated protein kinases activation in lipopolysaccharide-induced mastitis in mice, Inflammation Research 62 (2013) 9-15.

[55] B. Liu, N. Zhang, Z. Liu, Y. Fu, S. Feng, S. Wang, Y. Cao, D. Li, D. Liang, F. Li, X. Song, Z. Yang, RP105 involved in activation of mouse macrophages via TLR2 and TLR4 signaling, Molecular and Cellular Biochemistry 378 (2013) 183-193.

[56] Z. Liu, Z. Yang, Y. Fu, F. Li, D. Liang, E. Zhou, X. Song, W. Zhang, X. Zhang, Y. Cao, N. Zhang, Protective effect of gossypol on lipopolysaccharide-induced acute lung injury in mice, Inflammation Research 62 (2013) 499-506.

[57] Y. Fu, B. Liu, N. Zhang, Z. Liu, D. Liang, F. Li, Y. Cao, X. Feng, X. Zhang, Z. Yang, Magnolol inhibits lipopolysaccharide-induced inflammatory response by interfering with TLR4 mediated NF-kappa B and MAPKs signaling pathways, Journal of Ethnopharmacology 145 (2013) 193-199.

[58] Y. Fu, B. Liu, X. Feng, Z. Liu, D. Liang, F. Li, D. Li, Y. Cao, S. Feng, X. Zhang, N. Zhang, Z. Yang, Lipopolysaccharide increases Toll-like receptor 4 and downstream Toll-like receptor signaling molecules expression in bovine endometrial epithelial cells, Veterinary Immunology and Immunopathology 151 (2013) 20-27.

[59] Z. Yang, Y. Fu, B. Liu, E. Zhou, Z. Liu, X. Song, D. Li, N. Zhang, Farrerol regulates antimicrobial peptide expression and reduces Staphylococcus aureus internalization into bovine mammary epithelial cells, Microbial Pathogenesis 65 (2013) 1-6.

[60] D. Li, N. Zhang, Y. Cao, W. Zhang, G. Su, Y. Sun, Z. Liu, F. Li, D. Liang, B. Liu, M. Guo, Y. Fu, X. Zhang, Z. Yang, Emodin ameliorates lipopolysaccharide-induced mastitis in mice by inhibiting activation of NF-kappa B and MAPKs signal pathways, European journal of pharmacology 705 (2013) 79-85.

[61] M. Guo, N. Zhang, D. Li, D. Liang, Z. Liu, F. Li, Y. Fu, Y. Cao, X. Deng, Z. Yang, Baicalin plays an anti-inflammatory role through reducing nuclear factor-kappa B and p38 phosphorylation in S. aureus-induced mastitis, International immunopharmacology 16 (2013) 125-130.